Ondansetrona + dexametasona: compatibilidade

***

Ondansetron 0.10, 0.20, 0.40, and 0.64 mg/mL (as the hydrochloride salt) and dexamethasone phosphate 0.20 and 0.40 mg/mL (as the sodium salt) in 50-mL polyvinyl chloride containers and ondansetron 0.64 mg/mL (as the hydrochloride salt) and dexamethasone phosphate 0.20 and 0.40 mg/mL (as the sodium salt) in 50-mL polyester containers were stable for 30 days at 2-6 degrees Celsius followed by 48 hours at 22-23 degrees Celsius.

Ondansetron hydrochloride and dexamethasone sodium phosphate were not compatible when high concentrations were combined in polypropylene syringes.

Reference:Evrard B, Ceccato A, Gaspard O, Delattre L, Delporte JP. Stability of ondansetron hydrochloride and dexamethasone sodium phosphate in 0.9% sodium chloride and in 5% dextrose injection. Am J Health-Syst Pharm ; 54: 1065-1068. 1997